Hydrochloric Acid → 4'-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-amino]ethoxy]-3-(isopropylthio)-4-biphenylcarboxylic acid hydrochloride

HRID 2220437노트

반응식

HRID 2220437 반응식
[OH:1][C@H:2]([C:29]1[CH:34]=[CH:33][C:32]([OH:35])=[CH:31][CH:30]=1)[C@@H:3]([NH:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([O:23]C)=[O:22])=[C:17]([S:25][CH:26]([CH3:28])[CH3:27])[CH:16]=2)=[CH:11][CH:10]=1)[CH3:4].[OH-].[Na+].[ClH:38]>CO>[ClH:38].[OH:1][C@H:2]([C:29]1[CH:34]=[CH:33][C:32]([OH:35])=[CH:31][CH:30]=1)[C@@H:3]([NH:5][CH2:6][CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([OH:23])=[O:22])=[C:17]([S:25][CH:26]([CH3:28])[CH3:27])[CH:16]=2)=[CH:13][CH:14]=1)[CH3:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69103361methyl 4'-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-amino]ethoxy]-3-(isopropylthio)-4-biphenylcarboxylate

생성물 1

HCID 691028394'-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-amino]ethoxy]-3-(isopropylthio)-4-biphenylcarboxylic acid hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of methyl 4′-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethoxy]-3-(isopropylthio)-4-biphenylcarboxylate (110 mg) in methanol (1.65 ml) was added sodium hydroxide aqueous solution (1N 1.11 ml) and stirred at room temperature overnight. To the mixture was added hydrochloric acid aqueous solution (1N, 1.22 ml) and concentrated in vacuo. The residue was solved with methanol, added hydrogen chloride 1,4-dioxane solution (4M), concentrated in vacuo and dried to give 4′-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-amino]ethoxy]-3-(isopropylthio)-4-biphenylcarboxylic acid hydrochloride (97 mg).

후처리

  1. concentrationconcentrated in vacuo
  2. additionadded hydrogen chloride 1,4-dioxane solution (4M)
  3. concentrationconcentrated in vacuo
  4. customdried

출처 및 근거

ORD 기록
ord-706566f822f54639b63be178769e5a2d
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07417060B2

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