Hydrochloric Acid → HCID 69204095, 화합물

A mixture of methyl 4-{2-[(R)-2-(4-benzyloxy-3-methanesulfonylaminophenyl)-2-hydroxyethylamino]ethoxy}biphenyl-4-carboxylate (0.064 g), a 2 mol/L aqueous solution of sodium hydroxide (0.162 mL), ethanol (2 mL) and tetrahydrofuran (2 mL) was heated under reflux overnight. To the ice-cooled reaction mixture was added 2 mol/L hydrochloric acid (0.162 mL), and the solvent was evaporated under reduced pressure. The residue was washed with water to afford 4′-{2-[(R)-2-(4-benzyloxy-3-methanesulfonylaminophenyl)-2-hydroxyethylamino]ethoxy}biphenyl-4-carboxylic acid (0.06 g) as a crude product.