Hydrochloric Acid → 2-(5-(trifluoromethyl)-1H-indazol-3-ylamino)acetic acid

HRID 2225209

반응식

HRID 2225209 반응식
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[NH:12][CH2:13][C:14]([O:16]CC)=[O:15].[Li+].[OH-].CO.Cl>C1COCC1>[F:20][C:2]([F:1])([F:19])[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[NH:12][CH2:13][C:14]([OH:16])=[O:15]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3939Lithium HydroxideHCID 68469013ethyl 2-(5-(trifluoromethyl)-1H-indazol-3-ylamino)acetate

생성물 1

HCID 219911872-(5-(trifluoromethyl)-1H-indazol-3-ylamino)acetic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Preparation I6, Step 3: A sample of ethyl 2-(5-(trifluoromethyl)-1H-indazol-3-ylamino)acetate (75 mg) was dissolved in THF (6 mL). The resulting solution was charged successively with an aqueous solution of LiOH (12.5 mg in 2 mL water) and methanol (2 mL). The reaction mixture was stirred for 2 h before being acidified with 1N HCl and extracted with EtOAc. The organic extracts were combined, washed with water and brine, dried (sodium sulfate), filtered, and concentrated under reduced pressure to afford 2-(5-(trifluoromethyl)-1H-indazol-3-ylamino)acetic acid. MS found: (M+H)+=260.22.

후처리

  1. customPreparation I6, Step 3
  2. extractionextracted with EtOAc
  3. washwashed with water and brine
  4. dry with materialdried (sodium sulfate)
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-5b28191dd484457ca1b791e613ed416a
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07378409B2

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