Hydrochloric Acid → 2-Quinolone-3-carboxylic acid

HRID 2225333

반응식

HRID 2225333 반응식
[C:1]([OH:7])(=O)[CH2:2][C:3]([OH:5])=[O:4].[NH2:8][C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[CH:11]=O.N1CCCCC1.Cl>N1C=CC=CC=1>[C:3]([C:2]1[C:1](=[O:7])[NH:8][C:9]2[C:10]([CH:11]=1)=[CH:13][CH:14]=[CH:15][CH:16]=2)([OH:5])=[O:4]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 8082PiperidineHCID 682552-Aminobenzaldehyde

생성물 1

HCID 3324882-Quinolone-3-carboxylic acid

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
90 °C

실험 절차

2 Grams of malonic acid was dissolved in 15 ml of pyridine, then 1.2 g of o-aminobenzaldehyde and 2 ml of piperidine were added thereto, and the mixture was stirred at 90° C. for 5 hours. The reaction mixture was poured in an aqueous solution of hydrochloric acid and the crystals precipitated were collected by filtration. Recrystallized from methanol-chloroform to obtain 1.2 g of 3-carboxycarbostyril in the form of colorless needle-like crystals.

후처리

  1. customthe crystals precipitated
  2. filtrationwere collected by filtration
  3. customRecrystallized from methanol-chloroform

출처 및 근거

ORD 기록
ord-e9275bd61d724c5faffa0e0519491c3e
출처 데이터셋
uspto-grants-1994_09
특허 번호
USRE034722

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