Triethylamine → HCID 178483830, 화합물

HRID 2225531

반응식

HRID 2225531 반응식
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[CH:6]=[CH:7][C:8]([OH:10])=O.P(Cl)(OCC)(OCC)=O.C(N(CC)CC)C.[CH3:32][N:33]([CH3:44])[CH2:34][CH2:35][NH:36][C@H:37]1[CH2:42][CH2:41][C@H:40]([CH3:43])[CH2:39][CH2:38]1>CN(C)C1C=CN=CC=1.C(Cl)Cl>[CH3:32][N:33]([CH3:44])[CH2:34][CH2:35][N:36]([C@H:37]1[CH2:38][CH2:39][C@H:40]([CH3:43])[CH2:41][CH2:42]1)[C:8](=[O:10])[CH:7]=[CH:6][C:5]1[CH:11]=[CH:12][CH:13]=[C:3]([C:2]([F:1])([F:15])[F:14])[CH:4]=1

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 13139Diethyl chlorophosphateHCID 855273-Trifluoromethylcinnamic acidHCID 178483797HCID 178483797, 화합물

생성물 1

HCID 178483830HCID 178483830, 화합물

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

Using 1.3 g of 3-trifluoromethylcinnamic acid, 1.4 ml of diethyl chlorophosphate, 1.4 ml of triethylamine, 60 ml of methylene chloride, 1.4 ml of N-(2-dimethylaminoethyl)-trans-4-methylcyclohexylamine (Example 78), and 0.25 g of 4-dimethylaminopyridine, a reaction similar to that conducted in Example 81 was carried out. As a result, 2.25 g of N-(2-dimethylaminoethyl)-N-(trans-4-methylcyclohexyl)-3-trifluoromethylcinnamamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

후처리

  1. customa reaction similar to

출처 및 근거

ORD 기록
ord-a913824fcd0d427ba9caec9681c38fda
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05344845

연결된 노트

불러오는 중…