Hydrochloric Acid → (4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetic acid

HRID 2227099노트

반응식

HRID 2227099 반응식
[OH-:1].[Na+].[CH3:3][C:4]([CH3:17])=[CH:5][CH2:6][CH2:7][C:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]#N)[CH2:10][CH:9]=1.Cl.[OH2:19]>OO>[CH3:3][C:4]([CH3:17])=[CH:5][CH2:6][CH2:7][C:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([OH:19])=[O:1])[CH2:10][CH:9]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 18471789(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetonitrile

생성물 1

HCID 18471803(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetic acid

시약·촉매·용매 1

HCID 784Hydrogen Peroxide용매

실험 절차

To a solution of sodium hydroxide (10.5 g) in water (150 mL) and 30% hydrogen peroxide (50 mL) is added the nitrile 2A (R=4-Methyl-3-pentenyl) (10 g). The reaction mixture is stirred at reflux overnight. The reaction is then cooled to room temperature, and poured into a mixture of ice (30 g) and hydrochloric acid (22 mL). The acid product is extracted with ethyl acetate, and the combined organic layers are washed with brine and dried over magnesium sulfate. The solution is concentrated in vacuo.

후처리

  1. temperatureat reflux overnight
  2. extractionThe acid product is extracted with ethyl acetate
  3. washthe combined organic layers are washed with brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationThe solution is concentrated in vacuo

출처 및 근거

ORD 기록
ord-653a52b5aaee4cd8bec4f76a400e3192
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06413448B1

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