Ethanol → Aminolevulinic acid phosphate

HRID 222816

반응식

HRID 222816 반응식
Cl.[NH2:2][CH2:3][C:4](=[O:10])[CH2:5][CH2:6][C:7]([OH:9])=[O:8].[P:11](=[O:15])([OH:14])([OH:13])[OH:12].C(N(CC)CC)C.C(O)C>O>[P:11]([OH:15])([OH:14])([OH:13])=[O:12].[NH2:2][CH2:3][C:4](=[O:10])[CH2:5][CH2:6][C:7]([OH:9])=[O:8]

참가 물질

6

반응물 4

HCID 702EthanolHCID 1004Phosphoric AcidHCID 8471TriethylamineHCID 123608Aminolevulinic Acid Hydrochloride

생성물 1

HCID 24737828Aminolevulinic acid phosphate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A 40 g (239 mmol) portion of δ-aminolevulinic acid hydrochloride and 18 ml (263 mmol) of 85% phosphoric acid were dissolved in 120 ml of purified water, and 25.4 g mmol) of triethylamine was added dropwise thereto while stirring on an ice bath. After completion of the dropwise addition and subsequent stirring at room temperature for 10 minutes, 1.6 L of ethanol was added thereto and stirred. The thus precipitated precipitate was recovered by suction filtration and dried at room temperature for 16 hours under a reduced pressure. A 51 g (224 mmol) portion of δ-aminolevulinic acid phosphate was obtained at a yield of 93 mol %.

후처리

  1. additionAfter completion of the dropwise addition
  2. stirringsubsequent stirring at room temperature for 10 minutes
  3. stirringstirred
  4. filtrationThe thus precipitated precipitate was recovered by suction filtration
  5. customdried at room temperature for 16 hours under a reduced pressure

출처 및 근거

ORD 기록
ord-03aff9b54ec140d99b2fc56d12619989
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08207376B2

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