Ethanol → Aminolevulinic acid phosphate

HRID 222819

반응식

HRID 222819 반응식
Cl.[NH2:2][CH2:3][C:4](=[O:10])[CH2:5][CH2:6][C:7]([OH:9])=[O:8].[P:11](=[O:15])([OH:14])([OH:13])[OH:12].N1C=CC(C)=CC=1.C(O)C>O>[P:11]([OH:15])([OH:14])([OH:13])=[O:12].[NH2:2][CH2:3][C:4](=[O:10])[CH2:5][CH2:6][C:7]([OH:9])=[O:8]

참가 물질

6

반응물 4

HCID 702EthanolHCID 1004Phosphoric AcidHCID 79634-MethylpyridineHCID 123608Aminolevulinic Acid Hydrochloride

생성물 1

HCID 24737828Aminolevulinic acid phosphate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A 10.05 g (60.6 mmol) portion of δ-aminolevulinic acid hydrochloride and 4.5 ml (65.7 mmol) of 85% phosphoric acid were dissolved in 30 ml of purified water, and 5.83 g (62.7 mmol) of γ-picoline was added dropwise thereto while stirring. After completion of the dropwise addition and subsequent stirring at room temperature for 10 minutes, 400 ml of ethanol was added thereto and stirred. The thus precipitated precipitate was recovered by suction filtration and dried at room temperature for 19 hours under a reduced pressure. A 10.55 g (46.1 mmol) portion of δ-aminolevulinic acid phosphate was obtained at a yield of 77 mol %.

후처리

  1. additionAfter completion of the dropwise addition
  2. stirringsubsequent stirring at room temperature for 10 minutes
  3. stirringstirred
  4. filtrationThe thus precipitated precipitate was recovered by suction filtration
  5. customdried at room temperature for 19 hours under a reduced pressure

출처 및 근거

ORD 기록
ord-901946f65deb420a9baf0c01fe95683c
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08207376B2

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