Sodium Hydroxide → HCID 53776389, 화합물

HRID 22298노트

반응식

HRID 22298 반응식
[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([CH:9]=[CH:10][CH:11]=1)[O:5][CH2:6][C:7]#[N:8].Cl.[NH2:14][OH:15].[OH-].[Na+]>C(O)C.O>[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([CH:9]=[CH:10][CH:11]=1)[O:5][CH2:6][C:7](=[N:14][OH:15])[NH2:8]

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 22075474HCID 22075474, 화합물

생성물 1

HCID 53776389HCID 53776389, 화합물수율 90.2%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매2회

실험 절차

29.2 g (160.7 mmol) of 3-chloro-2-methyl-phenoxyacetonitrile are added to a solution of 13.5 g (194.2 mmol) of hydroxylamine hydrochloride, 7.7 g (194.2 mmol) of sodium hydroxide in 265 ml of ethanol and 68 ml of water. The mixture is heated at reflux temperature until the reaction is complete (approximately 48 to 60 hours) and the entire batch is subsequently stirred into 250 ml of water. The solid which precipitates in this process is separated off, washed with a small amount of water and dried. 31.1 g (90.2% of theory) of 3-chloro-2-methylphenoxyacetamide oxime are obtained.

후처리

  1. temperatureThe mixture is heated
  2. temperatureat reflux temperature until the reaction
  3. custom(approximately 48 to 60 hours)
  4. customThe solid which precipitates in this process
  5. customis separated off
  6. washwashed with a small amount of water
  7. customdried

출처 및 근거

ORD 기록
ord-aa0f88f5567d4fcda3a90af48f11be4b
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428047

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