Hydrochloric Acid → 2-Methoxy-5-(5-methylsulfonyltetrazol-1-yl)benzoic acid

HRID 2230630노트

반응식

HRID 2230630 반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]([S:18]([CH3:21])(=[O:20])=[O:19])=[N:16][N:15]=[N:14]2)=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].CO.[OH-].[Na+].Cl>ClCCl.O>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]([S:18]([CH3:21])(=[O:20])=[O:19])=[N:16][N:15]=[N:14]2)=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 18464688methyl 2-methoxy-5-(5-methylsulfonyl-1H-tetrazol-1-yl)benzoate

생성물 1

HCID 184644382-Methoxy-5-(5-methylsulfonyltetrazol-1-yl)benzoic acid

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

Combine methyl 2-methoxy-5-(5-methylsulfonyl-1H-tetrazol-1-yl)benzoate (5 mmol), methanol (10 mL), and a 1 M aqueous sodium hydroxide solution (6 mL, 6.0 mmol). After 18 hours, evaporate in vacuo to give a residue. Combine the residue, water (5 mL) and acidify by dropwise addition of a 1 M aqueous hydrochloric acid solution (6.5 mL). Evaporate in vacuo to give a residue. Combine the residue and dichloromethane and stir. Decant and add dichloromethane and stir. Decant and combine with the first decantate. Dry over Na2SO4, filter, and concentrate in vacuo to give the title compound.

후처리

  1. customevaporate in vacuo
  2. customto give a residue
  3. customEvaporate in vacuo
  4. customto give a residue
  5. customDecant
  6. additionadd dichloromethane
  7. stirringstir
  8. customDecant
  9. dry with materialDry over Na2SO4
  10. filtrationfilter
  11. concentrationconcentrate in vacuo

출처 및 근거

ORD 기록
ord-ccd1973a824242b4abd9090f72f3df82
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06423704B1

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