Methanol → 7-ethoxy-6-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-1-benzopyran-2-one

HRID 22309

반응식

HRID 22309 반응식
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[C:7]([O:17][CH2:18][CH3:19])=[CH:8][C:9]2[O:14][C:13](=[O:15])[CH:12]=[CH:11][C:10]=2[CH:16]=1.[C:20]1([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.CO.C([O-])(=O)/C=C/C([O-])=O>C(O)C>[CH2:18]([O:17][C:7]1[C:6]([O:5][CH2:4][CH2:3][CH2:2][N:29]2[CH2:30][CH2:31][N:26]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:27][CH2:28]2)=[CH:16][C:10]2[CH:11]=[CH:12][C:13](=[O:15])[O:14][C:9]=2[CH:8]=1)[CH3:19]

참가 물질

6

반응물 4

HCID 887MethanolHCID 70961-PhenylpiperazineHCID 5460307FumarateHCID 199277346-(3-chloropropoxy)-7-ethoxy-2H-1-benzopyran-2-one

생성물 1

HCID 199276617-ethoxy-6-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-1-benzopyran-2-one수율 57%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

Method A (26 h at 60° C.); starting materials: 6-(3-chloropropoxy)-7-ethoxy-2H-1-benzopyran-2-one (see example 70) and 1-phenylpiperazine; yield 57%; fusion point 151° to 153° (from methanol and ethanol). Fumarate: method E; yield 78%; fusion point 170° to 173° C. (from ethanol).

후처리

  1. customMethod A (26 h at 60° C.)

출처 및 근거

ORD 기록
ord-d60a35bd97fd4ef6ac58e78b0a9da410
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428038

연결된 노트

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