Methyl iodide → 5,6-Difluoro-1,2-dimethyl-1H-benzimidazole

HRID 2231264노트

반응식

HRID 2231264 반응식
[CH3:1][C:2]1[NH:3][C:4]2[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:5]=2[N:6]=1.[H-].[Na+].[CH3:15]I>CN(C)C=O>[CH3:15][N:6]1[C:5]2[CH:7]=[C:8]([F:12])[C:9]([F:11])=[CH:10][C:4]=2[N:3]=[C:2]1[CH3:1]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 21193128HCID 21193128, 화합물

생성물 1

HCID 212862805,6-Difluoro-1,2-dimethyl-1H-benzimidazole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Using the alkylation procedure of Preparation A-2, 3.6 g of 2-methyl-5,6-difluorobenzimidazole, 1.03 g of 50% sodium hydride and 1.33 ml of methyl iodide in 40 ml of dimethylformamide gave 1.1 g of the desired product as an orange solid.

출처 및 근거

ORD 기록
ord-5281f79268e747f2a86c404d6e0d51dc
출처 데이터셋
uspto-grants-1988_11
특허 번호
US04782050

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