Hydrochloric Acid → HCID 59295961, 화합물

HRID 2233397노트

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HRID 2233397 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[C:5]2[C:13]([O:15]C)=[O:14].[OH-].[Na+].Cl>CO>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[C:5]2[C:13]([OH:15])=[O:14]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 53429435Methyl 6-fluoro-1-oxo-1,2-dihydroisoquinoline-4-carboxylate

생성물 1

HCID 59295961HCID 59295961, 화합물수율 95.3%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
80 °C

실험 절차

To a solution of methyl 6-fluoro-1-oxo-1,2-dihydroisoquinoline-4-carboxylate (1.3 g) in methanol (3 ml) was added a aqueous solution (3 ml) of sodium hydroxide (1 g) and the reaction mixture was heated at 80° C. for 3 h. The reaction was cooled to 20° C. and carefully acidified with concentrated hydrochloric acid. The white precipitate was isolated by filtration, washed with water and methanol to yield the title compound (1.16 g)

후처리

  1. temperatureThe reaction was cooled to 20° C.
  2. customThe white precipitate was isolated by filtration
  3. washwashed with water and methanol

출처 및 근거

ORD 기록
ord-0868ada0a3724d0eac7566f608a05aaf
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709500B2

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