Pyridine → HCID 178433931, 화합물

HRID 2234099

반응식

HRID 2234099 반응식
[O:1]=[C:2]1[C:7]([C:8]([NH:10][NH2:11])=O)=[CH:6][C:5]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[N:4][NH:3]1.[C:18]([NH2:21])(=S)[CH3:19].C(N(CC)CC)C.N1C=CC=CC=1>C(O)CCC>[CH3:19][C:18]1[NH:21][C:8]([C:7]2[C:2](=[O:1])[NH:3][N:4]=[C:5]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)[CH:6]=2)=[N:10][N:11]=1

참가 물질

6

반응물 4

HCID 1049PyridineHCID 8471TriethylamineHCID 2723949ThioacetamideHCID 127902392,3-Dihydro-3-oxo-6-(4-pyridinyl)-4-pyridazinecarboxylic acid hydrazide

생성물 1

HCID 178433931HCID 178433931, 화합물

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

A mixture of 100 mg of 3-oxo-6-pyridin-4-yl-2,3-dihydro-pyridazine-4-carboxylic acid hydrazide, 130 mg thioacetamide, 87 mg triethylamine, 1 ml of pyridine and 5 ml of butanol is refluxed for 15 hours. After cooling and stirring at room temperature a solid precipitated is collected by filtration, washed with cold isopropanol and dried in vacuo.

후처리

  1. temperatureis refluxed for 15 hours
  2. temperatureAfter cooling
  3. customprecipitated
  4. filtrationis collected by filtration
  5. washwashed with cold isopropanol
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-bbdbd6c97f2c44b9b9dd0ae2b695d54f
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709466B2

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