Sodium borohydride → (2,6-Dichloro-3-methoxyphenyl)methanol

HRID 2235210

반응식

HRID 2235210 반응식
[Cl:1][C:2]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[C:6]([Cl:12])[C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>C(O)C>[Cl:1][C:2]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[C:6]([Cl:12])[C:3]=1[CH2:4][OH:5]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 149271732,6-Dichloro-3-methoxybenzaldehyde

생성물 1

HCID 21980844(2,6-Dichloro-3-methoxyphenyl)methanol수율 93.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Dissolve 2,6-dichloro-3-methoxy-benzaldehyde (10 g, 48.8 mmol) in ethanol (330 ml) add sodiumborohydride (1.8 g, 48.8 mmol) and stir at room temperature over night. Partition reaction mixture between water and ethyl acetate separate layers wash organic with brine, dry over sodium sulfate, filter and concentrate to yield 9.43 g (93%) of (2,6-Dichloro-3-methoxy-phenyl)-methanol.

후처리

  1. customPartition
  2. customreaction mixture between water and ethyl acetate
  3. customseparate layers
  4. washwash organic with brine
  5. dry with materialdry over sodium sulfate
  6. filtrationfilter
  7. concentrationconcentrate

출처 및 근거

ORD 기록
ord-5126c216c3c74222ac698c14d245ede7
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07713979B2

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