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Hydrochloric Acid → 5-[3,5-Dichloro-4-(1-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-phenyl]-thiophene-2-carboxylic acid

HRID 2235327
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인쇄 미리보기

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HRID 2235327 반응식
[Li+].[OH-].C[O:4][C:5]([C:7]1[S:8][C:9]([C:12]2[CH:17]=[C:16]([Cl:18])[C:15]([CH2:19][CH:20]3[CH2:24][CH2:23][N:22]([CH:25]4[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]4)[C:21]3=[O:31])=[C:14]([Cl:32])[CH:13]=2)=[CH:10][CH:11]=1)=[O:6].CCOC(C)=O.Cl>O1CCOCC1>[Cl:32][C:14]1[CH:13]=[C:12]([C:9]2[S:8][C:7]([C:5]([OH:6])=[O:4])=[CH:11][CH:10]=2)[CH:17]=[C:16]([Cl:18])[C:15]=1[CH2:19][CH:20]1[CH2:24][CH2:23][N:22]([CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)[C:21]1=[O:31]
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6

반응물 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 8857Ethyl AcetateHCID 592993875-[3,5-Dichloro-4-(1-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-phenyl]-thiophene-2-carboxylic acid methyl ester

생성물 1

HCID 592994935-[3,5-Dichloro-4-(1-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-phenyl]-thiophene-2-carboxylic acid

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
50 °C

실험 절차

Add 1.0 mL of LiOH (2.0 N aq.) to a solution of 5-[3,5-Dichloro-4-(1-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-phenyl]-thiophene-2-carboxylic acid methyl ester (85 mg, 0.182 mmol) in 3.0 mL of dioxane and heat to 50° C. After 3 hours, a TLC shows the reaction to be complete. Dilute the reaction with DCM /H2O (50/50), acidify with 1.0N HCl, extract with ethyl acetate, and dry the combined organic layers with sodium sulfate. Filter off the sodium sulfate and concentrate to give the title compound. LC/MS (API) m/z: 452.0 (M+1).

후처리

  1. customthe reaction
  2. additionDilute
  3. extractionextract with ethyl acetate
  4. dry with materialdry the combined organic layers with sodium sulfate
  5. filtrationFilter off the sodium sulfate
  6. concentrationconcentrate

출처 및 근거

ORD 기록
ord-5281614b7388400c99098fc838bf2d33
출처 데이터셋
uspto-grants-2010_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07713979B2

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