Hydrochloric Acid → 3-Methoxy-4-(prop-2-ynyloxy)benzoic acid

HRID 2236366노트

반응식

HRID 2236366 반응식
[CH2:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]([C:9]([O:11]CC#C)=[O:10])=[CH:7][C:6]=1[O:17][CH3:18])[C:2]#[CH:3].[OH-].[Na+].Cl>CO>[CH2:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]([C:9]([OH:11])=[O:10])=[CH:7][C:6]=1[O:17][CH3:18])[C:2]#[CH:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 593017652-Propynyl 4-(2-propynyloxy)-3-methoxybenzoate

생성물 1

HCID 131214803-Methoxy-4-(prop-2-ynyloxy)benzoic acid수율 107.7%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

To 50 ml of methanol were added 13.2 g of 2-propynyl 4-(2-propynyloxy)-3-methoxybenzoate and 40 ml of 15% aqueous sodium hydroxide solution and the mixture obtained was stirred at room temperature for 8 hours and at 50° C. for 2 hours. Then, the reaction mixture was added to hydrochloric acid for acidification. Crystals precipitated were collected by filtration and dried to obtain 12.0 g of 4-(2-propynyloxy)-3-methoxybenzoic acid represented by the formula:

후처리

  1. customthe mixture obtained
  2. customCrystals precipitated
  3. filtrationwere collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-95fa9f52a0284dd3b043d2312caf63eb
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07714168B2

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