[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[C:10](=[O:14])[NH:9][C:8](=[O:15])[CH2:7]2)([O-:3])=[O:2].C[C:17]([O:19][C:20](C)=O)=O.CN(C)C=O.C(OC)(OC)OC>CCOCC>[CH3:17][O:19]/[CH:20]=[C:7]1/[C:8](=[O:15])[NH:9][C:10](=[O:14])[C:11]2[C:6]/1=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:13][CH:12]=2To a stirred mixture of 0.41 g (2.0 mmol) of 6-nitroisoquinoline-1,3(2H,4H)-dione, 3.2 ml (34 mmol) of Ac2O, and 0.80 ml of N,N-dimethylformamide is added 0.44 ml (4.0 mmol) of trimethyl orthoformate. The mixture is heated to 125° and maintained for 30 m, cooled, diluted with ether, and stirred for 10 m. The resulting brown solid is filtered, washed with ether, and dried to give 372 mg (74%); 1H NMR (DMSO-d6) δ 11.55 (s, 1H), 8.99 (d, J=2.0 Hz, 1H), 8.30 (d, J=8.6 Hz, 1H), 8.19 (dd J=2.0, 8.6 Hz, 1H), 4.33 (s, 3H).
불러오는 중…
