Water → alpha-(2-Methylpropylidene)pyridine-2-acetonitrile

HRID 223698

반응식

HRID 223698 반응식
O.[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]#[N:10].[CH:11](=O)[CH:12]([CH3:14])[CH3:13].N1CCCCC1>C1C=CC=CC=1.C(O)(=O)C>[CH3:11][CH:12]([CH3:14])[CH:13]=[C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][N:2]=1)[C:9]#[N:10]

참가 물질

7

반응물 4

HCID 962WaterHCID 6561IsobutyraldehydeHCID 8082PiperidineHCID 75959Pyridine-2-acetonitrile

생성물 1

HCID 90767alpha-(2-Methylpropylidene)pyridine-2-acetonitrile

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 241Benzene용매

실험 절차

In a flask equipped with a water separator are placed 7 g of 2-pyridyl acetonitrile, 12.8 g of isobutyraldehyde, 0.9 ml of acetic acid, 0.18 ml of piperidine and 250 ml of dry benzene. The mixture is heated under reflux for 3 hours. After cooling, the reaction mixture is washed with water, the organic phase is dried over sodium sulfate then the solvent is evaporated to dryness.

후처리

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 3 hours
  3. temperatureAfter cooling
  4. washthe reaction mixture is washed with water
  5. dry with materialthe organic phase is dried over sodium sulfate
  6. customthe solvent is evaporated to dryness

출처 및 근거

ORD 기록
ord-8c24038a3fed4ea884fea50cdda5a581
출처 데이터셋
uspto-grants-1982_10
특허 번호
US04356177

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