Hydrochloric Acid → 3-(Dimethylcarbamoyl)benzoic acid
반응식
[CH3:1][N:2]([CH3:15])[C:3]([C:5]1[CH:6]=[C:7]([CH:12]=[CH:13][CH:14]=1)[C:8]([O:10]C)=[O:9])=[O:4].O.[OH-].[Li+].Cl>CO.O>[CH3:1][N:2]([CH3:15])[C:3]([C:5]1[CH:6]=[C:7]([CH:12]=[CH:13][CH:14]=1)[C:8]([OH:10])=[O:9])=[O:4]참가 물질
6
실험 절차
Methyl 3-(N,N-dimethylcarbamoyl)benzoate (2.30 g, 11.1 mmol) obtained in Step 1 was dissolved in a mixed solvent (1:1) (50 mL) of methanol and water, and lithium hydroxide monohydrate (932 mg, 22.2 mmol) was added thereto, followed by stirring at room temperature for 1 hour. 3 mol/L hydrochloric acid was added to the reaction mixture to adjust the pH to 3, and the precipitated solid was collected by filtration to afford 3-(N,N-dimethylcarbamoyl)benzoic acid (2.12 g, 99%).
후처리
- additionwas added
- filtrationthe precipitated solid was collected by filtration
출처 및 근거
- ORD 기록
- ord-4a7d20cdb0004de197cd15dc7c90f664
- 출처 데이터셋
- uspto-grants-2010_05
- 특허 번호
- US07718808B2
반응 노트
불러오는 중…