Iodoethane → 6-Bromo-4-ethyl-2,2,7-trimethyl-4H-benzo[1,4]oxazin-3-one

HRID 2239240노트

반응식

HRID 2239240 반응식
[Br:1][C:2]1[C:3]([CH3:15])=[CH:4][C:5]2[O:10][C:9]([CH3:12])([CH3:11])[C:8](=[O:13])[NH:7][C:6]=2[CH:14]=1.[OH-].[K+].[CH2:18](I)[CH3:19]>CS(C)=O>[Br:1][C:2]1[C:3]([CH3:15])=[CH:4][C:5]2[O:10][C:9]([CH3:11])([CH3:12])[C:8](=[O:13])[N:7]([CH2:18][CH3:19])[C:6]=2[CH:14]=1

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 14797Potassium HydroxideHCID 685856146-Bromo-2,2,7-trimethyl-4H-benzo[1,4]oxazin-3-one

생성물 1

HCID 685847416-Bromo-4-ethyl-2,2,7-trimethyl-4H-benzo[1,4]oxazin-3-one수율 95%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매2회

실험 절차

Compound 1B (1.0 g, 3.7 mmol) was dissolved in 25 mL of DMSO and added to a prestirred 2.0 M solution of potassium hydroxide (415 mg, 7.4 mmol) in DMSO. Next, ethyl iodide (0.6 mL, 7.4 mmol) was added and the reaction stirred at room temperature overnight. The reaction was quenched with 75 mL of water and extracted with dichloromethane. The combined organic extracts were dried over magnesium sulfate, filtered and excess solvent removed to yield 1.04 g (95%) of desired product. MS (electrospray): mass calculated for C13H16BrNO2, 297.04; m/z found 298, [M+H]+.

후처리

  1. customThe reaction was quenched with 75 mL of water
  2. extractionextracted with dichloromethane
  3. dry with materialThe combined organic extracts were dried over magnesium sulfate
  4. filtrationfiltered
  5. customexcess solvent removed

출처 및 근거

ORD 기록
ord-699c33e2a6b94064bceaf2f677b9452e
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07723326B2

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