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Hydrochloric Acid → HCID 67243180, 화합물

HRID 2239530
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HRID 2239530 반응식
CC(C)([O-])C.[K+].[C:7]([NH:11][S:12]([CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)(=[O:14])=[O:13])([CH3:10])([CH3:9])[CH3:8].[C:22](OCC)(=[O:28])[C:23](OCC)=[O:24].Cl>C1COCC1>[C:7]([N:11]1[C:23](=[O:24])[C:22]([OH:28])=[C:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[S:12]1(=[O:14])=[O:13])([CH3:10])([CH3:8])[CH3:9]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 7268Diethyl OxalateHCID 562762N-tert-butyl-1-phenylmethanesulfonamideHCID 23665647Potassium tert-butoxide

생성물 1

HCID 67243180HCID 67243180, 화합물수율 471.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
150 °C

실험 절차

Potassium tert-butoxide (0.845 g, 10.56 mmol) was added to a solution of N-(tert-butyl)-1-phenylmethanesulfonamide (1.2 g, 5.28 mmol) and diethyl oxalate (0.85 mL, 6.33 mmol) in THF (8 mL) and the mixture was heated at 150° C. for 15 mins in a microwave reactor. The reaction mixture was acidified with 1M HCl, the THF was evaporated and the residue was Example tracted with DCM. Evaporation and trituration of the residue with petroleum ether gave the title compound (7 g, 63%) as a solid; 1H NMR (500 MHz, CDCl3): δ 7.44-7.32 (m, 5H), 3.90 (br s, 1H), 1.36 (s, 9H); Mass Spectrum: M−H+ 280

후처리

  1. customthe THF was evaporated
  2. customEvaporation and trituration of the residue with petroleum ether

출처 및 근거

ORD 기록
ord-341c029a19ad4f78b1f3eb821c87ae47
출처 데이터셋
uspto-grants-2010_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07723333B2

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