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Hydrochloric Acid → 6-(4-Fluorophenyl)-N4-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-ylamino)phenyl]pyrimidine-2,4-diamine

HRID 2240261
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HRID 2240261 반응식
[F:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:15]=[CH:14][N:13]=[C:12]2[N:16](COCC[Si](C)(C)C)[CH:17]=[CH:18][C:11]=12.Cl[C:28]1[CH:33]=[C:32]([C:34]2[CH:39]=[CH:38][C:37]([F:40])=[CH:36][CH:35]=2)[N:31]=[C:30]([NH2:41])[N:29]=1.Cl.[OH-].[Na+]>O>[F:40][C:37]1[CH:36]=[CH:35][C:34]([C:32]2[N:31]=[C:30]([NH2:41])[N:29]=[C:28]([NH:8][C:6]3[CH:5]=[CH:4][C:3]([NH:9][C:10]4[CH:15]=[CH:14][N:13]=[C:12]5[NH:16][CH:17]=[CH:18][C:11]=45)=[C:2]([F:1])[CH:7]=3)[CH:33]=2)=[CH:39][CH:38]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric Acid2회HCID 14798Sodium HydroxideHCID 112183534-Chloro-6-(4-fluorophenyl)pyrimidin-2-amineHCID 593049942-Fluoro-N-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)benzene-1,4-diamine

생성물 1

HCID 593049756-(4-Fluorophenyl)-N4-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-ylamino)phenyl]pyrimidine-2,4-diamine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

100 mg (0.27 mmol) of 2-fluoro-N1-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)benzene-1,4-diamine and 63 mg (0.28 mmol) of 4-chloro-6-(4-fluorophenyl)pyrimidine-2-amine are suspended in 3 ml of water. 39 μl (0.40 mmol) of a 37% strength hydrochloric acid solution are then added, and the mixture is heated under reflux overnight. After addition of a further 39 μl (0.40 mmol) of a 37% strength hydrochloric acid solution, the mixture is again reacted under reflux overnight. Using 1N aqueous sodium hydroxide solution, the suspension is then adjusted to pH 10, resulting in the precipitation of crystals. The solid is filtered off, washed with a little water and then dissolved in DMSO and purified by preparative RP-HPLC.

후처리

  1. temperaturethe mixture is heated
  2. temperatureunder reflux overnight
  3. customthe mixture is again reacted
  4. temperatureunder reflux overnight
  5. customresulting in the precipitation of crystals
  6. filtrationThe solid is filtered off
  7. washwashed with a little water
  8. dissolutiondissolved in DMSO
  9. custompurified by preparative RP-HPLC

출처 및 근거

ORD 기록
ord-1602cf236aca4247a7989579182d4c3a
출처 데이터셋
uspto-grants-2010_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07723347B2

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