Triethylamine → 2-Bromo-N-(5-methyl-isoxazol-3-yl)-acetamide

HRID 2240292노트

반응식

HRID 2240292 반응식
[CH3:1][C:2]1[O:6][N:5]=[C:4]([NH2:7])[CH:3]=1.C(N(CC)CC)C.[Br:15][CH2:16][C:17](Br)=[O:18]>C(Cl)(Cl)Cl>[Br:15][CH2:16][C:17]([NH:7][C:4]1[CH:3]=[C:2]([CH3:1])[O:6][N:5]=1)=[O:18]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 61147Bromoacetyl bromideHCID 661723-Amino-5-methylisoxazole

생성물 1

HCID 64850652-Bromo-N-(5-methyl-isoxazol-3-yl)-acetamide

시약·촉매·용매 1

HCID 6212Chloroform용매2회

반응 조건

온도
-40 °C

실험 절차

To a stirred solution of 5-methyl-isoxazol-3-ylamine (4.0 g, 40.8 mmol) and triethylamine (6.8 ml, 50 mmol) in chloroform (20 ml) cooled to −40° C., is added bromoacetyl bromide (3.9 ml, 44.9 mmol) in chloroform (20 ml). The reaction mixture is stirred at −40° C. for 30 minutes and then allowed to warm to room temperature. The resultant suspension is filtered, washed with DCM and dried in vacuo to yield the titled compound.

후처리

  1. temperatureto warm to room temperature
  2. filtrationThe resultant suspension is filtered
  3. washwashed with DCM
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-e1cfa6179eae4288a4def748a48c1cf0
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07723356B2

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