Diethyl Malonate → Diethyl isopentylmalonate

HRID 22417

반응식

HRID 22417 반응식
[Na].[C:2]([O:10][CH2:11][CH3:12])(=[O:9])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].[O-]CC.[Na+:16].[CH2:17](Br)[CH2:18][CH:19]([CH3:21])[CH3:20]>C(O)C>[O-:5][CH2:4][CH3:3].[Na+:16].[CH2:17]([CH:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[C:2]([O:10][CH2:11][CH3:12])=[O:9])[CH2:18][CH:19]([CH3:21])[CH3:20]

참가 물질

7

반응물 4

HCID 7761Diethyl MalonateHCID 78911-Bromo-3-methylbutaneHCID 2723922Sodium ethoxideHCID 5360545Sodium

생성물 2

HCID 79384Diethyl isopentylmalonateHCID 2723922Sodium ethoxide

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

Sodium ethoxide was prepared from sodium metal (9.1 g) and freshly distilled absolute ethanol (250 ml). Diethyl malonate (63.5 g) was added to sodium ethoxide in ethanol, and the mixture was stirred at 60°-70° C. for 50 min. Isoamyl bromide (60 g) was added, and the reaction mixture was heated under reflux overnight. After the usual work-up, the resulting crude product was distilled under reduced pressure to give diethyl isoamylmalonate. Yield: 71.7 g (78%).

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureunder reflux overnight
  3. distillationAfter the usual work-up, the resulting crude product was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-ba34f5f565a642ce817fb30dcee7b722
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428062

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