Hydrochloric Acid → 6-(Hydroxymethyl)pyridine-3-carboxylic acid

HRID 2242219노트

반응식

HRID 2242219 반응식
C[O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][OH:11])=[N:6][CH:5]=1.Cl>[OH-].[Na+].CO>[OH:11][CH2:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:12])=[O:2])=[CH:5][N:6]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 7894146-Hydroxymethyl-nicotinic acid methyl ester

생성물 1

HCID 147221306-(Hydroxymethyl)pyridine-3-carboxylic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

실험 절차

A solution of 6-hydroxymethyl-nicotinic acid methyl ester (0.400 g, 2.38 mmol) in 1.0 N NaOH (25.0 mL) and methanol (10.0 mL) was heated at 80° C. for 1 hour. The reaction mixture was cooled to room temperature and the pH was adjusted to 7.0 with 1.0 N HCl. The reaction mixture was concentrated in vacuo and the resulting salt was slurried in DMF and filtered to provide the title compound.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-59423fface8b427fb41c791457caea82
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07671043B2

반응 노트

불러오는 중…