Hydrochloric Acid → HCID 178440783, 화합물

HRID 2242258노트

반응식

HRID 2242258 반응식
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:15][C:14]([C:16]3[CH:32]=[CH:31][C:19]([CH2:20][NH:21][C@@H:22]4[CH2:25][C@H:24]([C:26]([O:28]CC)=[O:27])[CH2:23]4)=[CH:18][CH:17]=3)=[N:13][N:12]=2)=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].[OH-].[Na+].[ClH:35]>CO>[ClH:35].[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]([C:11]2[O:15][C:14]([C:16]3[CH:32]=[CH:31][C:19]([CH2:20][NH:21][C@@H:22]4[CH2:25][C@H:24]([C:26]([OH:28])=[O:27])[CH2:23]4)=[CH:18][CH:17]=3)=[N:13][N:12]=2)=[CH:9][CH:10]=1)[CH:2]([CH3:4])[CH3:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178472517HCID 178472517, 화합물

생성물 1

HCID 178440783HCID 178440783, 화합물수율 61%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of ethyl cis-3-({4-[5-(4-isobutylphenyl)-1,3,4-oxadiazol-2-yl]benzyl}amino)cyclobutane carboxylate (0.300 g, 0.692 mmol), 1N NaOH (6.0 mL), and methanol (5 mL) was heated in a microwave oven at 100° C. for 3 minutes. The reaction mixture was cooled to room temperature and pH was adjusted to 7 with 1N HCl, causing a white solid to precipitate. The reaction mixture was filtered and the solid was washed with water, then treated with 1N HC in ether to give the title compound (0.170 g, 61% yield).

후처리

  1. customto precipitate
  2. filtrationThe reaction mixture was filtered
  3. washthe solid was washed with water
  4. additiontreated with 1N HC in ether

출처 및 근거

ORD 기록
ord-54b445a372f3416ea4b1d310f9d5982e
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07671043B2

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