Water → HCID 178512066, 화합물

HRID 2242886

반응식

HRID 2242886 반응식
[Br:1][C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[C:6]([Br:8])[N:7]=1.[O:10]1[CH:14]=[CH:13][CH:12]=[C:11]1[C:15]#[N:16].[Al+3].[Cl-].[Cl-].[Cl-].O>ClC(Cl)C>[Br:1][C:2]1[C:3]([NH:9][C:15]([C:11]2[O:10][CH:14]=[CH:13][CH:12]=2)=[NH:16])=[N:4][CH:5]=[C:6]([Br:8])[N:7]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 692452-FuronitrileHCID 6200042-Amino-3,5-dibromopyrazineHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 178512066HCID 178512066, 화합물수율 72%

시약·촉매·용매 1

HCID 63651,1-Dichloroethane용매

실험 절차

A solution of 3,5-dibromo-pyrazin-2-ylamine (608 mg, 2.4 mmol), furan-2-carbonitrile (297 uL, 3.39 mmol) and AlCl3 (320 mg, 2.4 mmol) in dichloroethane (6 ml) was heated at 115° C. overnight. The reaction was cooled to room temperature and water (5 ml) was added. After 30 minutes, the resulting precipitate was collected and purified by column chromatography (SiO2, THF) to afford 595 mg (72%) of N-(3,5-dibromo-pyrazin-2-yl)-furan-2-carboxamidine as a yellow solid. 1H NMR (300 MHz, DMSO-d6) δ 6.73 (dd, J=3.4, 1.8 Hz, 1H), 7.3 (dd, J=3.1 Hz, 1H), 7.98 (s, 1H), 8.49(s, 1H), 8.69 (br. s, 1H).

후처리

  1. customthe resulting precipitate was collected
  2. custompurified by column chromatography (SiO2, THF)

출처 및 근거

ORD 기록
ord-e652283c74b74d7c9aa07581e79364ed
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07674791B2

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