홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrochloric Acid → 7-Methoxy-1-oxo-1H-pyrimido[6,1-b]benzthiazole-4-carboxylic acid

HRID 224346
노트
인쇄 미리보기

반응식

HRID 224346 반응식
COC1C=CC2N3C(=O)C(C(OCC)=O)=CN=C3SC=2C=1.[OH-].[Na+].Cl.[SH:25][C:26]1[CH:31]=[C:30]([O:32][CH3:33])[CH:29]=[CH:28][C:27]=1[N:34]1[C:39](=O)[C:38]([C:41]([OH:43])=[O:42])=[CH:37][NH:36][C:35]1=[O:44]>C(O)C>[CH3:33][O:32][C:30]1[CH:29]=[CH:28][C:27]2[N:34]3[C:35](=[O:44])[N:36]=[CH:37][C:38]([C:41]([OH:43])=[O:42])=[C:39]3[S:25][C:26]=2[CH:31]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 838855Ethyl 8-methoxy-4-oxopyrimido[2,1-b][1,3]benzothiazole-3-carboxylateHCID 233328051-(2-Mercapto-4-methoxyphenyl)-5-carboxypyrimidine-2,6-dione

생성물 1

HCID 233327897-Methoxy-1-oxo-1H-pyrimido[6,1-b]benzthiazole-4-carboxylic acid

시약·촉매·용매 1

HCID 702
Ethanol
용매

실험 절차

4.5 g. Ethyl 8-methoxy-4-oxo-4H-pyrimido[2,1-b]-benzthiazole-3-carboxylate (prepared by the method described by Alaimo, J. Het. Chem., 10, 769/1973) are mixed with a mixture of 75 ml. 10% aqueous sodium hydroxide solution and 25 ml. ethanol and heated under reflux for 30 minutes. After neutralizing the reaction mixture with 2 N hydrochloric acid, 1-(2-mercapto-4-methoxyphenyl)-5-carboxypyrimidine-2,6-dione precipitates out. The yield is 3.5 g. (80% of theory); m.p. 266°-267° C. (decomp.).

후처리

  1. addition, 10, 769/1973) are mixed with a mixture of 75 ml
  2. temperatureunder reflux for 30 minutes
  3. customprecipitates out

출처 및 근거

ORD 기록
ord-9cd5f563df97405abd2db26ff91696b7
출처 데이터셋
uspto-grants-1980_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04232024

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트