Hydrochloric Acid → 4-Bromo-2-isopropylbenzoic acid
반응식
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[C:4]([CH:12]([CH3:14])[CH3:13])[CH:3]=1.O.[OH-].[Li+].O1CCOCC1.Cl>O>[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[C:4]([CH:12]([CH3:14])[CH3:13])[CH:3]=1참가 물질
6
실험 절차
A mixture of methyl 4-bromo-2-isopropylbenzoate (0.41 g) and lithium hydroxide monohydrate (0.67 g) in water (1 mL)/1,4-dioxane (3 mL) was stirred at room temperature for 5 days. 2 mol/L hydrochloric acid (10 mL) was added to the mixture, and the resulting mixture was extracted with ethyl acetate. The solvent was evaporated under reduced pressure, and the residue was recrystallized from ethyl acetate/n-hexane to afford the title compound (0.276 g).
후처리
- extractionthe resulting mixture was extracted with ethyl acetate
- customThe solvent was evaporated under reduced pressure
- customthe residue was recrystallized from ethyl acetate/n-hexane
출처 및 근거
- ORD 기록
- ord-ee837d1ca830429aa28aa6efdf2199a7
- 출처 데이터셋
- uspto-grants-2010_03
- 특허 번호
- US07674938B2
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