2,6-Dimethoxybenzoic Acid → 3-Chloro-2,6-dimethoxybenzoic acid

HRID 224417

반응식

HRID 224417 반응식
S(Cl)([Cl:4])(=O)=O.[CH3:6][O:7][C:8]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[C:9]=1[C:10]([OH:12])=[O:11]>C(Cl)(Cl)Cl>[Cl:4][C:16]1[C:8]([O:7][CH3:6])=[C:9]([C:13]([O:17][CH3:18])=[CH:14][CH:15]=1)[C:10]([OH:12])=[O:11]

참가 물질

4

반응물 2

HCID 151092,6-Dimethoxybenzoic AcidHCID 24648Sulfuryl chloride

생성물 1

HCID 6121993-Chloro-2,6-dimethoxybenzoic acid

시약·촉매·용매 1

HCID 6212Chloroform용매2회

반응 조건

온도
50 °C

실험 절차

A solution of 16.2 ml (0.2 mol) of sulphuryl chloride in 100 ml of chloroform is added dropwise while stirring to a solution of 36.4 g (0.2 mol) of 2,6-dimethoxybenzoic acid in 300 ml of chloroform. The mixture is heated for 0.5 h at 50° C. and left overnight at room temperature. The solvent is evaporated and the residue recrystallized from isopropyl ether--light petroleum. Yield: 35.4 g, m.p. 132°-33° C.

후처리

  1. customThe solvent is evaporated
  2. customthe residue recrystallized from isopropyl ether

출처 및 근거

ORD 기록
ord-71ed333a1fb041258c5bd0fea60222fc
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04232037

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