2,6-Dimethoxybenzoic Acid → 3-Chloro-2,6-dimethoxybenzoic acid
반응식
S(Cl)([Cl:4])(=O)=O.[CH3:6][O:7][C:8]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[C:9]=1[C:10]([OH:12])=[O:11]>C(Cl)(Cl)Cl>[Cl:4][C:16]1[C:8]([O:7][CH3:6])=[C:9]([C:13]([O:17][CH3:18])=[CH:14][CH:15]=1)[C:10]([OH:12])=[O:11]참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
A solution of 16.2 ml (0.2 mol) of sulphuryl chloride in 100 ml of chloroform is added dropwise while stirring to a solution of 36.4 g (0.2 mol) of 2,6-dimethoxybenzoic acid in 300 ml of chloroform. The mixture is heated for 0.5 h at 50° C. and left overnight at room temperature. The solvent is evaporated and the residue recrystallized from isopropyl ether--light petroleum. Yield: 35.4 g, m.p. 132°-33° C.
후처리
- customThe solvent is evaporated
- customthe residue recrystallized from isopropyl ether
출처 및 근거
- ORD 기록
- ord-71ed333a1fb041258c5bd0fea60222fc
- 출처 데이터셋
- uspto-grants-1980_11
- 특허 번호
- US04232037
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