Acetaldehyde → 4-(1-Fluorocyclopropyl)benzoic acid

HRID 2244327노트

반응식

HRID 2244327 반응식
[O:1]=O.[F:3][C:4]1([C:7]2[CH:12]=[CH:11]C(C)=[CH:9][CH:8]=2)[CH2:6][CH2:5]1.[CH:14](=[O:16])[CH3:15]>C(O)(=O)C.O.O.O.O.C([O-])(=O)C.[Co+2].C([O-])(=O)C>[F:3][C:4]1([C:7]2[CH:12]=[CH:11][C:15]([C:14]([OH:1])=[O:16])=[CH:9][CH:8]=2)[CH2:6][CH2:5]1

참가 물질

6

반응물 3

HCID 177AcetaldehydeHCID 977OxygenHCID 68703601HCID 68703601, 화합물

생성물 1

HCID 665992344-(1-Fluorocyclopropyl)benzoic acid수율 46%

시약·촉매·용매 2

HCID 61372Cobalt(II) acetate tetrahydrate촉매HCID 176Acetic Acid용매

실험 절차

Oxygen was slowly bubbled at 100° C. through a solution of 1-(1-fluoro-cyclopropyl)-4-methyl-benzene (470 mg, 3.13 mmol), cobalt(II)acetate tetrahydrate (117 mg, 0.46 mmol), and acetaldehyde (0.18 mL, 3.1 mmol) in acetic acid (30 mL) over 16 h. After cooling, the reaction mixture was evaporated and the residue triturated in water. The precipitate was collected by filtration to produce the title compound (257 mg, 46%). Light green solid, MS (EI) 180.1 (M+).

후처리

  1. temperatureAfter cooling
  2. customthe reaction mixture was evaporated
  3. customthe residue triturated in water
  4. filtrationThe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-61b79f41742d4eef8ce098b7f76c38d3
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07678818B2

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