Hydrochloric Acid → HCID 11508375, 화합물

HRID 2244416노트

반응식

HRID 2244416 반응식
[CH3:1][C:2]1[S:3][C:4]([NH:21][C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)=[C:5]([C:7]([NH:9][C:10]2[N:15]=[C:14]([CH2:16][O:17]C(=O)C)[CH:13]=[CH:12][CH:11]=2)=[O:8])[N:6]=1.[OH-].[Na+].O.Cl>CO>[OH:17][CH2:16][C:14]1[N:15]=[C:10]([NH:9][C:7]([C:5]2[N:6]=[C:2]([CH3:1])[S:3][C:4]=2[NH:21][C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)=[O:8])[CH:11]=[CH:12][CH:13]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 11560023HCID 11560023, 화합물

생성물 1

HCID 11508375HCID 11508375, 화합물수율 85.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of acetic acid 6-{[2-methyl-5-(pyridin-3-ylamino)-thiazole-4-carbonyl]-amino}-pyridin-2-ylmethyl ester (0.046 g, 0.12 mmol) in methanol (20.00 ml) was treated with a 2N solution of NaOH in water (1.00 ml, 2.00 mmol). After 15 min stirring at room temperature, the mixture was acidified with HCl 2N, and the solvents removed. The residue was purified by flash chromatography (dichloromethane/methanol) to yield the title compound (0.035 g, 85%) as a light yellow solid, MS (ISP): m/e=342.1 (M+H+).

후처리

  1. customthe solvents removed
  2. customThe residue was purified by flash chromatography (dichloromethane/methanol)

출처 및 근거

ORD 기록
ord-f444a7d7c732431db19a2bd65588c207
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07678815B2

반응 노트

불러오는 중…