Oxygen → ((4-Bromophenyl)ethynyl)triisopropylsilane

HRID 2246489

반응식

HRID 2246489 반응식
[CH:1]([Si:4]([C:11]#[CH:12])([CH:8]([CH3:10])[CH3:9])[CH:5]([CH3:7])[CH3:6])([CH3:3])[CH3:2].C(N(CC)CC)C.O=O.[Br:22][C:23]1[CH:28]=[CH:27][C:26](I)=[CH:25][CH:24]=1>O1CCCC1.[Cu](I)I.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[Br:22][C:23]1[CH:28]=[CH:27][C:26]([C:12]#[C:11][Si:4]([CH:5]([CH3:6])[CH3:7])([CH:1]([CH3:3])[CH3:2])[CH:8]([CH3:10])[CH3:9])=[CH:25][CH:24]=1

참가 물질

8

반응물 4

HCID 977OxygenHCID 8471TriethylamineHCID 115221-Bromo-4-iodobenzeneHCID 2734682(Triisopropylsilyl)acetylene

생성물 1

HCID 57809595((4-Bromophenyl)ethynyl)triisopropylsilane

시약·촉매·용매 3

HCID 83717Copper iodide촉매HCID 178418476HCID 178418476, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

11.6 mL triisopropylsilylacetylen and 14.4 mL triethylamine followed by 0.2 g copper iodide and 0.73 g bis-(triphenylphosphine)-palladium dichloride are added under argon to an oxygen-free solution of 15.0 g 4-bromo-1-iodo-benzene in 150 mL dry tetrahydrofuran. The solution is stirred for 16 h at ambient temperature and then filtered through Celite and evaporated down. The residue is purified by chromatography on silica gel (cyclohexane).

후처리

  1. filtrationfiltered through Celite
  2. customevaporated down
  3. customThe residue is purified by chromatography on silica gel (cyclohexane)

출처 및 근거

ORD 기록
ord-99738f654bff4a7da2cd2e1ca416f1a1
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07687469B2

연결된 노트

불러오는 중…