Phthalic Anhydride → 7-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)heptanoic acid

HRID 224980

반응식

HRID 224980 반응식
[C:1]1(=[O:11])[O:6][C:4](=O)[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[NH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20]>C(OCC)(=O)C>[C:4]1(=[O:6])[N:12]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])[C:1](=[O:11])[C:2]2=[CH:10][CH:9]=[CH:8][CH:7]=[C:3]12

참가 물질

4

반응물 2

HCID 6811Phthalic AnhydrideHCID 135807-Aminoheptanoic acid

생성물 1

HCID 136226357-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)heptanoic acid수율 50.8%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of phthalic anhydride (5.3 g.) and 7-amino-heptanoic acid (5.8 g.) was heated at 185°-190° C. for 40 minutes and then cooled. The cooled partially solidified product was dissolved in ethyl acetate and the solution washed several times with dilute HCl. The organic layer was dried (MgSO4), filtered and evaporated to dryness and the residue recrystallized from acetic acid to give 7-phthalimidoheptanoic acid (5 g.), m.p. 112°-115° C.

후처리

  1. temperaturewas heated at 185°-190° C. for 40 minutes
  2. temperaturecooled
  3. temperatureThe cooled partially solidified product
  4. washthe solution washed several times with dilute HCl
  5. dry with materialThe organic layer was dried (MgSO4)
  6. filtrationfiltered
  7. customevaporated to dryness
  8. customthe residue recrystallized from acetic acid

출처 및 근거

ORD 기록
ord-69f78c92517845a3a70f96df5c84e7fd
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04234735

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