Hydrochloric Acid → 1-(6-Chloro-benzo[b]thiophen-2-ylmethyl)-5-(2-methoxy-ethoxy)-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

HRID 2250447노트

반응식

HRID 2250447 반응식
[Li+].[OH-].C([O:5][C:6]([C:8]1[N:21]([CH2:22][C:23]2[S:27][C:26]3[CH:28]=[C:29]([Cl:32])[CH:30]=[CH:31][C:25]=3[CH:24]=2)[C:11]2=[CH:12][N:13]=[C:14]([O:16][CH2:17][CH2:18][O:19][CH3:20])[CH:15]=[C:10]2[CH:9]=1)=[O:7])C.Cl>O.C1COCC1.CO>[Cl:32][C:29]1[CH:30]=[CH:31][C:25]2[CH:24]=[C:23]([CH2:22][N:21]3[C:11]4=[CH:12][N:13]=[C:14]([O:16][CH2:17][CH2:18][O:19][CH3:20])[CH:15]=[C:10]4[CH:9]=[C:8]3[C:6]([OH:7])=[O:5])[S:27][C:26]=2[CH:28]=1

참가 물질

7

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 692267011-(6-Chloro-benzo[b]thiophen-2-ylmethyl)-5-(2-methoxy-ethoxy)-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl ester

생성물 1

HCID 692268441-(6-Chloro-benzo[b]thiophen-2-ylmethyl)-5-(2-methoxy-ethoxy)-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
50 °C

실험 절차

8 mL of a 1M LiOH solution in water were added to solution of 890 mg (2 mmol) 1-(6-Chloro-benzo[b]thiophen-2-ylmethyl)-5-(2-methoxy-ethoxy)-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl ester in 30 mL THF and 15 mL MeOH and the mixture was stirred for 1 h at 50° C. 16 mL of 1N HCl were added, the organic solvent removed in vacuo and the residue extracted with ethyl acetate. The organic phase was dried over MgSO4. After filtration the solvent was evaporated yielding the desired product. Yield: 810 mg.

후처리

  1. customthe organic solvent removed in vacuo
  2. extractionthe residue extracted with ethyl acetate
  3. dry with materialThe organic phase was dried over MgSO4
  4. filtrationAfter filtration the solvent
  5. customwas evaporated

출처 및 근거

ORD 기록
ord-dc4a66ec97444ac8ab1e15d98774a983
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07317027B2

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