Water → HCID 69199600, 화합물

HRID 2252237노트

반응식

HRID 2252237 반응식
[CH:1](OCC)=[O:2].[H-].[Na+].[CH3:8][O:9][C:10]1[CH:18]=[C:17]2[C:13]([CH2:14][CH2:15][C:16]2=[O:19])=[CH:12][CH:11]=1.O>C1C=CC=CC=1>[OH:2][CH:1]=[C:15]1[CH2:14][C:13]2[C:17](=[CH:18][C:10]([O:9][CH3:8])=[CH:11][CH:12]=2)[C:16]1=[O:19]

참가 물질

6

반응물 4

HCID 962WaterHCID 8025Ethyl formateHCID 24758Sodium hydrideHCID 3340366-Methoxy-1-Indanone

생성물 1

HCID 69199600HCID 69199600, 화합물수율 91%

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

To a mixture of ethyl formate (15.75 mL, 0.195 mol) and NaH (60%, 7.80 g, 0.195 mol) in benzene (550 mL) was added a suspension of 6-methoxy-indan-1-one (15.81 g, 0.0974 mol) in benzene (150 mL) dropwise at 0° C. The reaction mixture was stirred at room temperature overnight and treated with water. The solid was filtered, washed with water, and oven dried to give the desired product (16.86 g, 91%). The product may exist in sodium salt form, however, it was carried into the next reaction without further characterization. MS (DCI/NH3) m/z: 191.1 (M+H)+; 1H NMR (300 MHz, DMSO-D6) δ ppm 3.50 (s, 2H) 3.80 (s, 3H) 7.13-7.20 (m, 2H) 7.47 (d, J=8.14 Hz, 1H) 7.74 (s, brd, 1H).

후처리

  1. additionwas added
  2. filtrationThe solid was filtered
  3. washwashed with water, and oven
  4. customdried

출처 및 근거

ORD 기록
ord-f92fa25e67e74244afe60b5de043f96f
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07320986B2

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