Hydrochloric Acid → Ethanesulfonic acid (6-chloro-5-p-tolyl-pyrimidin-4-yl)-amide

HRID 2252720

반응식

HRID 2252720 반응식
Cl[C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)=[C:6]([Cl:15])[N:5]=[CH:4][N:3]=1.[K+].[CH2:17]([S:19]([NH-:22])(=[O:21])=[O:20])[CH3:18].Cl>CS(C)=O>[Cl:15][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:22][S:19]([CH2:17][CH3:18])(=[O:21])=[O:20])[C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 219795544,6-Dichloro-5-(4-methylphenyl)pyrimidineHCID 59645266Ethanesulfonamide potassium salt

생성물 1

HCID 59645274Ethanesulfonic acid (6-chloro-5-p-tolyl-pyrimidin-4-yl)-amide수율 39.6%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

4,6-dichloro-5-(p-tolyl)-pyrimidine (717 mg) was dissolved in DMSO (5 ml) and ethanesulfonamide potassium salt (927 mg) was added and stirring continued for 14 h at rt. The solution was poured onto ice/water and acidified by 2 N HCl to pH 3-4. The precipitate was filtered off and washed with water and diethylether to give ethanesulfonic acid (6-chloro-5-p-tolyl-pyrimidin-4-yl)-amide (370 mg) as a white powder. LC-MS: tR: 4.09, [M+H]+: 312.10.

후처리

  1. additionThe solution was poured onto ice/water
  2. filtrationThe precipitate was filtered off
  3. washwashed with water and diethylether

출처 및 근거

ORD 기록
ord-e0e2465a1b7a483a85ef5148029c218f
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07323465B2

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