Water → HCID 19744765, 화합물

HRID 2254427노트

반응식

HRID 2254427 반응식
[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[CH2:12]O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Br)(Br)[Br:18].O>C(Cl)(Cl)Cl>[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[CH2:12][Br:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 24614Phosphorus tribromideHCID 54519030123926-88-5

생성물 1

HCID 19744765HCID 19744765, 화합물수율 99%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

The resulting acetylene compound (116 mg) was dissolved in 1 ml of chloroform, and 0.1 ml of phosphorus tribromide was added. The mixture was stirred at room temperature for 1 hour. Water and chloroform were added to the reaction mixture. The organic layer was separated, washed with a saturated aqueous solution of sodium hydrogen carbonate and water, and then dried over anhydrous sodium sulfate. The desiccant was removed by filtration, and the filtrate was evaporated under reduced pressure to give 150 mg (yield 99%) of the captioned compound as a colorless oil.

후처리

  1. customThe organic layer was separated
  2. washwashed with a saturated aqueous solution of sodium hydrogen carbonate and water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe desiccant was removed by filtration
  5. customthe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-35538b78fcb54098ad39eec989362db4
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05234946

반응 노트

불러오는 중…