Sulfuric Acid → Fadrozole

HRID 22551

반응식

HRID 22551 반응식
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[N:14]3[CH:15]=[N:16][CH:17]=[C:13]3[CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1)=O.[NH:18]=[N+]=[N-].S(=O)(=O)(O)O>C1C=CC=CC=1>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[N:14]3[CH:15]=[N:16][CH:17]=[C:13]3[CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1)#[N:18]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 24530Hydrazoic acidHCID 140971985-(p-Formylphenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

생성물 1

HCID 59693Fadrozole

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A solution of 2.01 g of 5-(p-formylphenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine and 0.96 g of hydrazoic acid in 30 ml benzene is maintained by external cooling at room temperature, while 0.8 ml of concentrated sulfuric acid is added dropwise. The reaction mixture is stirred for 2 h and neutralized. The organic phase is separated, dried over sodium sulfate and evaporated to yield an oil which is chromatographed on silica gel with ethyl acetate to yield the title compound.

후처리

  1. additionis added dropwise
  2. customThe organic phase is separated
  3. dry with materialdried over sodium sulfate
  4. customevaporated
  5. customto yield an oil which
  6. customis chromatographed on silica gel with ethyl acetate

출처 및 근거

ORD 기록
ord-a545b507d80343d3b599544805a9709c
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428160

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