Sodium Hydroxide → Ethyl 2,7-diazabicyclo[3.3.0]octane-2-carboxylate

HRID 2255685노트

반응식

HRID 2255685 반응식
[CH:1]12[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH:5]1[CH2:4][CH2:3][N:2]2[C:16]([O:18][CH2:19][CH3:20])=[O:17].[OH-].[Na+]>C(Cl)(Cl)Cl>[CH:1]12[CH2:8][NH:7][CH2:6][CH:5]1[CH2:4][CH2:3][N:2]2[C:16]([O:18][CH2:19][CH3:20])=[O:17]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 191009335-(1,1-Dimethylethyl) 1-ethyl hexahydropyrrolo[3,4-b]pyrrole-1,5-dicarboxylate

생성물 1

HCID 15070028Ethyl 2,7-diazabicyclo[3.3.0]octane-2-carboxylate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

15.2 g (53.3 mol) of 2-ethyl 7-tert.-butyl 2,7-diazabicyclo[3.3.0]octane-2,7-dicarboxylate in 100 ml of chloroform are heated under reflux for five hours with 10.5 g (55.3 mol) of para-toluenesulphoic acid. The mixture is washeds with 50 ml of 10% strength sodium hydroxide solution, the organic phase is dried over potassium carbonate and concentrated, and the residue is distilled.

후처리

  1. dry with materialthe organic phase is dried over potassium carbonate
  2. concentrationconcentrated
  3. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-1d3c889c1bd3449bb7eadfc4c870dee8
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05241076

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