Water → 4-(Trifluoromethyl)indoline

HRID 225572노트

반응식

HRID 225572 반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][NH:7]2.C([BH3-])#N.[Na+].O.[OH-].[Na+]>C(O)(=O)C>[F:13][C:2]([F:1])([F:12])[C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][CH2:6][NH:7]2

참가 물질

6

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 5003444Sodium cyanoborohydrideHCID 198037034-(Trifluoromethyl)-1H-indole

생성물 1

HCID 162444454-(Trifluoromethyl)indoline수율 76%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

4.4 mmol of 4-trifluoromethyl-1H-indole were dissolved in 8 ml acetic acid. 8.8 mmol of sodium cyanoborohydride were added at once and the reaction mixture stirred at room temperature for 3.5 hours. 20 ml of water were added. The reaction mixture is treated with aqueous sodium hydroxide 40% until basic. Extraction with ethyl acetate yields the crude title compound as a yellowish waxy solid. Yield=76%. MS (m/e): 188.4 ([M+H]+, 97%).

후처리

  1. extractionExtraction with ethyl acetate

출처 및 근거

ORD 기록
ord-1bc62934a31c4a219546eb3e7d81dd16
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07557114B2

반응 노트

불러오는 중…