Hydrochloric Acid → 2-(4-n-Propylphenylthio)nonanoic acid

HRID 2257158

반응식

HRID 2257158 반응식
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10][CH:11]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[C:12]([O:14]CC)=[O:13])=[CH:6][CH:5]=1)[CH2:2][CH3:3].[OH-].[Na+].Cl>CO>[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10][CH:11]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1)[CH2:2][CH3:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14995384Ethyl 2-(4-n-Propylphenylthio)nonanoate

생성물 1

HCID 149953862-(4-n-Propylphenylthio)nonanoic acid수율 96%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution containing 5.7 (0.017 mole) of the title compound of Example 1, 35 ml of 1N aqueous sodium hydroxide solution (0.035 mole) and 3 ml methanol was refluxed overnight. The resulting solution was cooled to room temperature, acidified to pH 1.5 with 2N aqueous hydrochloric acid and extracted with 3×50 ml ethyl acetate. The combined ethyl acetate extracts were washed with 50 ml water and 50 ml saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and concentrated in vacuo to yield the title compound as an oil (5.0 g, 96% yield) which was used in the subsequent reaction without further purification.

후처리

  1. temperaturewas refluxed overnight
  2. extractionextracted with 3×50 ml ethyl acetate
  3. washThe combined ethyl acetate extracts were washed with 50 ml water and 50 ml saturated aqueous sodium chloride solution
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-e724042210d34632af98c871d08c3b04
출처 데이터셋
uspto-grants-1997_08
특허 번호
US05656634

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