Isophthalaldehyde → 3-(2-(7-Chloroquinolin-2-yl)vinyl)benzaldehyde

HRID 22595

반응식

HRID 22595 반응식
[CH:1](=[O:10])[C:2]1[CH:9]=[CH:8][CH:7]=[C:4]([CH:5]=O)[CH:3]=1.[Cl:11][C:12]1[CH:21]=[C:20]2[C:15]([CH:16]=[CH:17][C:18]([CH3:22])=[N:19]2)=[CH:14][CH:13]=1>C(OC(=O)C)(=O)C.CCOCC>[Cl:11][C:12]1[CH:21]=[C:20]2[C:15]([CH:16]=[CH:17][C:18]([CH:22]=[CH:5][C:4]3[CH:3]=[C:2]([CH:9]=[CH:8][CH:7]=3)[CH:1]=[O:10])=[N:19]2)=[CH:14][CH:13]=1

참가 물질

5

반응물 2

HCID 34777IsophthalaldehydeHCID 1383957-Chloro-2-methylquinoline

생성물 1

HCID 533948533-(2-(7-Chloroquinolin-2-yl)vinyl)benzaldehyde

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 7918Acetic Anhydride용매

실험 절차

A solution of isophthalaldehyde (4.0 g) and 7-chloroquinaldine (5.39 g) in acetic anhydride was heated at 125° in an oil bath for 48 hours. The reaction was cooled to room temperature, diluted with ether (30 mL) and the resulting suspension was stirred vigorously. The solid title compound was collected by filtration and was used as such in the next step.

후처리

  1. filtrationThe solid title compound was collected by filtration

출처 및 근거

ORD 기록
ord-82aa24b70650476f8934154e035255ed
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428171

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