Acetyl chloride → HCID 18423181, 화합물

HRID 2260566노트

반응식

HRID 2260566 반응식
[Cl-].[Al+3].[Cl-].[Cl-].[CH3:5][C:6]([NH:14][C:15](=[O:17])[CH3:16])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:7].[C:18](Cl)(=[O:20])[CH3:19]>ClC(Cl)C>[C:18]([C:11]1[CH:10]=[CH:9][C:8]([C:6]([NH:14][C:15](=[O:17])[CH3:16])([CH3:5])[CH3:7])=[CH:13][CH:12]=1)(=[O:20])[CH3:19]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 10749810N-(2-phenylpropan-2-yl)acetamide

생성물 1

HCID 18423181HCID 18423181, 화합물수율 66%

시약·촉매·용매 1

HCID 63651,1-Dichloroethane용매

실험 절차

Aluminum chloride (41.5 g) was portionwise added to a solution (75 ml) of N-(1-methyl-1-phenylethyl)acetamide (25 g) and acetyl chloride (16.6 g) in dichloroethane under ice-cooling. The mixture was stirred at said temperature for 1 hour and then at 50°-60° C. for 1 hour. After completion of the reaction, the reaction mixture was poured into ice water and extracted with chloroform. The extract was washed with water, dried and concentrated under reduced pressure to give crystals which were then recrystallized from ethyl acetate-isopropyl ether to give 20.4 g of N-(1-(4-acetylphenyl)-1-methylethyl)acetamide.

후처리

  1. temperaturecooling
  2. customfor 1 hour
  3. customAfter completion of the reaction
  4. extractionextracted with chloroform
  5. washThe extract was washed with water
  6. customdried
  7. concentrationconcentrated under reduced pressure
  8. customto give crystals which
  9. customwere then recrystallized from ethyl acetate-isopropyl ether

출처 및 근거

ORD 기록
ord-a5a1bba2bce64818b2e7422e8fcfc918
출처 데이터셋
uspto-grants-1995_12
특허 번호
US05478838

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