217 mg of 8-(1-Ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine (11.0 mmol), 227 mg of 3-bromo-2-methyl-benzo[b]thiophene (1.0 mmol), 26.2 mg of triphenylphosphine (0.1 mmol) and 650 mg of cesium carbonate (2.0 mmol) are placed into a reaction vial with 3 ml of dry DMF. N2 gas is bubbled in for 10 min and 34 mg of palladium acetate (0.05 mmol) is added. The reaction vial is capped with a Teflon cap and heated at 130° C. overnight. The reaction mixture is concentrated and applied onto a silica-gel chromatography column (Hexane:AcOEt:2M NH3 in MeOH=10:2:1) to give the title compound 119 mg (33%). mass spectrum (m/e): 364; 1H-NMR (CDCl3): 7.86 (m, 1H), 7.31 (m, 3H), 6.72 (s, 1H), 3.44 (m, 1H), 2.47 (s, 3H), 2.42 (s, 3H), 1.90 (m, 4H), 0.95 m, 6H) ppm.
