Dimethyl Sulfoxide → N-[4-(2-oxopyrrolidin-1-yl)phenyl]-4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carboxamide

HRID 2263233노트

반응식

HRID 2263233 반응식
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:12]=[CH:11][C:10]([N:13]([C:22]([O:24]CC(Cl)(Cl)Cl)=O)C(OCC(Cl)(Cl)Cl)=O)=[CH:9][CH:8]=1.[C:30]1([C:36]2[N:37]=[C:38]([N:41]3[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]3)[S:39][CH:40]=2)[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.C(N(C(C)C)CC)(C)C.CS(C)=O>O>[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:8]=[CH:9][C:10]([NH:13][C:22]([N:44]2[CH2:45][CH2:46][N:41]([C:38]3[S:39][CH:40]=[C:36]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[N:37]=3)[CH2:42][CH2:43]2)=[O:24])=[CH:11][CH:12]=1

참가 물질

6

반응물 4

HCID 679Dimethyl SulfoxideHCID 81531DiisopropylethylamineHCID 7124681-(4-Phenyl-1,3-thiazol-2-yl)piperazineHCID 86625512Bis(2,2,2-trichloroethyl) [4-(2-oxopyrrolidin-1-yl)phenyl]imidodicarbonate

생성물 1

HCID 68780098N-[4-(2-oxopyrrolidin-1-yl)phenyl]-4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carboxamide수율 68.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of bis(2,2,2-trichloroethyl) [4-(2-oxopyrrolidin-1-yl)phenyl]imidodicarbonate (200 mg, 0.379 mmol), 1-(4-phenyl-1,3-thiazol-2-yl)piperazine (196 mg, 0.758 mmol), diisopropylethylamine (0.132 ml, 0.758 mmol) and dimethyl sulfoxide (4 ml) was stirred at 70° C. for 24 hours, the reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The extract was washed with water, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residue was recrystallized from ethyl acetate to give 116 mg (68.2%) of the desired product as a solid.

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationThe solvent was distilled off under reduced pressure
  5. customthe residue was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-0ee3de035623480993988107af2a96e6
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07851473B2

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