2-Propanethiol → 3-(2-Isopropylthio-6-trifluoromethyl-pyridin-3-yl)-acrylic acid

반응식

Cl[C:2]1[C:7]([CH:8]=[CH:9][C:10]([OH:12])=[O:11])=[CH:6][CH:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[N:3]=1.[CH3:17][CH:18]([SH:20])[CH3:19].[H-].[Na+]>>[CH:18]([S:20][C:2]1[C:7]([CH:8]=[CH:9][C:10]([OH:12])=[O:11])=[CH:6][CH:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[N:3]=1)([CH3:19])[CH3:17]

참가 물질

반응물 3

HCID 63642-Propanethiol

HCID 24758Sodium hydride

HCID 723356323-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid

생성물 1

HCID 687816783-(2-Isopropylthio-6-trifluoromethyl-pyridin-3-yl)-acrylic acid수율 36.3%

실험 절차

3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (245 mg, 0.974 mmol) was reacted with 2-propanthiol (240 mg, 3.15 mmol) and sodium hydride (143 mg, 3.56 mmol) to afford the title compound (103 mg) after purification by column chromatography (Hex/EtOAc=2.5/1).

출처 및 근거

ORD 기록: ord-2e6d13fe45764c3b919ebb84e24e2033
출처 데이터셋: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07858621B2

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