Hydrochloric Acid → [8-chloro-3-(4-chlorophenylsulfanyl)-4-difluoromethoxy-2-methyl-quinolin-5-yloxy]acetic Acid

HRID 2266474노트

반응식

HRID 2266474 반응식
C[O:2][C:3](=[O:30])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]2[C:7]=1[C:8]([O:26][CH:27]([F:29])[F:28])=[C:9]([S:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=1)[C:10]([CH3:17])=[N:11]2.[OH-].[Na+].Cl>O1CCCC1>[Cl:16][C:13]1[CH:14]=[CH:15][C:6]([O:5][CH2:4][C:3]([OH:30])=[O:2])=[C:7]2[C:12]=1[N:11]=[C:10]([CH3:17])[C:9]([S:18][C:19]1[CH:20]=[CH:21][C:22]([Cl:25])=[CH:23][CH:24]=1)=[C:8]2[O:26][CH:27]([F:28])[F:29]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68780463[8-chloro-3-(4-chlorophenylsulfanyl)-4-difluoromethoxy-2-methylquinolin-5-yloxy]acetic Acid Methyl Ester

생성물 1

HCID 57742534[8-chloro-3-(4-chlorophenylsulfanyl)-4-difluoromethoxy-2-methyl-quinolin-5-yloxy]acetic Acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of [8-chloro-3-(4-chlorophenylsulfanyl)-4-difluoromethoxy-2-methylquinolin-5-yloxy]acetic acid methyl ester (0.044 g), tetrahydrofuran (3.0 mL) and 1.0 M aqueous sodium hydroxide solution (0.15 mL) was stirred at room temperature for 1 hour. The solution was acidified by the addition of 1.0 M aqueous hydrochloric acid and the solvent removed under reduced pressured. The residue was diluted with ethyl acetate and this mixture washed with water and then dried over magnesium sulfate. The solvent was removed under reduced pressure and the resulting solid washed with dichloromethane and dried to afford title compound, 0.024 g.

후처리

  1. customthe solvent removed
  2. additionThe residue was diluted with ethyl acetate
  3. washthis mixture washed with water
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent was removed under reduced pressure
  6. washthe resulting solid washed with dichloromethane
  7. customdried

출처 및 근거

ORD 기록
ord-f3cd9a5d3112483b944eb766f8fd4a39
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858640B2

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