Sodium Hydroxide → 4-(5-Fluoro-2-methoxyphenyl)piperidine
반응식
C([N:3]1[CH2:8][CH2:7][CH:6]([C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=2[O:16][CH3:17])[CH2:5][CH2:4]1)=O.[OH-].[Na+]>Cl>[F:15][C:13]1[CH:12]=[CH:11][C:10]([O:16][CH3:17])=[C:9]([CH:6]2[CH2:7][CH2:8][NH:3][CH2:4][CH2:5]2)[CH:14]=1참가 물질
4
실험 절차
The crude product of 1-formyl-4-(5-fluoro-2-methoxy-phenyl)-piperidine (0.80 g, 3.4 mmole) was dissolved in HCl (16 mL, 0.5 N) and McOH (5 mL), and the mixture was brought to reflux for 16 hours. The mixture was cooled to room temperature and basified with NaOH (2.5 N), and extracted with EtOAc (3×25 mL) to give 4-(5-fluoro-2-methoxy-phenyl)-piperidine which was used directly without further purification.
후처리
- temperatureto reflux for 16 hours
- extractionextracted with EtOAc (3×25 mL)
출처 및 근거
- ORD 기록
- ord-bfa284ed9e1e4d60b2189ca976242b82
- 출처 데이터셋
- uspto-grants-2001_12
- 특허 번호
- US06326381B1
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